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FPRL1 Agonist II, C43
An orally available, stable, pyrazolone derivative that acts as a potent prototypic agonist of human formyl-peptide-like 1 receptor (hFPRL1; FPR2) (EC50 = 44 nM). Also shown to block polymorphonuclear neutrophil (PMN) migration in a dose-dependent manner, irrespective of the type of stimulant applied. Reported to act by activating extracellular loop I, while the downstream signaling effects are attributed to its loop II region. Does not affect several other protein targets studied, such as p38a, CXCR2, histamine receptor, and TRPV1 (~10 mM). Exhibit suitable pharmacokinetic properties, such as low clearance (126 ml/h/kg) and a half-life of ~2.78 hours. Shown to significantly reduce edema in mouse ear (~50 mg/kg) following oral administration.
产品信息
Form Light brown powder
Molar mass 384.9
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥93% by HPLC
Solubility DMSO
Chemical formula C20H21ClN4O2
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |