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Dafadine-A
(5-((2,6-Dimethylphenoxy)methyl)isoxazol-3-yl)(4-(pyridin-4-yl)piperidin-1-yl)methanone, 4-(1-((5-((2,6-Dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine, DAF-9 Cytochrome P450 Inhibitor, Dafadine-A
A cell-permeable isoxazoloamide compound that specifically inhibits DAF-9 activity in C. elegans (~20 µM) without affecting the activity of DAF-12 and sterol- and oxysterol-metabolizing P450s. Reversibly targets the catalytic heme iron of DAF-9 cytochrome p450 and induce a constitutive dauer (Daf-c), distal-tip cell migration (Mig) and protruding vulval (Pvl) phenotypes in wild-type C.elegans (at ~25 µM). Also, shown to be one of the most potent inhibitors of CYP27A1, the mammalian ortholog of DAF-9. Robustly promotes dauer formation (non-aging stress-resistant alternative third larval stage) only in wild type C. elegans and extends their life span by about 29%.
产品信息
Form Light beige powder
Molar mass 391.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C23H25N3O3
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |