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Daminozide
N,N-Dimethylamino-succinamic acid, Succinic acid-2,2-dimethylhydrazide, 4-(2,2-Dimethylhydrazinyl)-4-oxobutanoic acid, BHC100 Inhibitor VI, KDM2A Inhibitor, KIAA1718 Inhibitor VI, LSD Inhibitor VI, PHF8 Inhibitor, JHDM Inhibitor VI, Histone Lysine Demethylase Inhibitor XII, LSD1 Inhibitor VI
A dimethylamino substituted succinamate that, in addition to its well known use as a plant growth regulator, also acts as an inhibitor against histone lysine demthylases KDM2A, LSD1 (KDM7A; KIAA1718), and PHF8 (IC50 = 1.5, 2.1, and 0.55 µM, respectively), but not KDM3A, KDM4E, KDM5C, KDM6B, or three hydroxylases (IC50 >100 µM). Substrate-competition and/or active site Iron chelating likely accounts for the inhibitory activity against the FAD-dependent LSD1, while 2-oxoglutarate (2-OG) competition (Ki = 1.97 µM) appears as the major mode of action against KDM2A.
产品信息
Form White powder
Molar mass 160.2
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥98% by NMR
Solubility H2O
Chemical formula C6H12N2O3
CAS number 1596-84-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic
安全标示
S Phrase S: 36/37/39
Wear suitable protective clothing, gloves and eye/face protection.
R Phrase R: 40
Limited evidence of a carcinogenic effect. |