D-Amino Acid Oxidase Inhibitor III, AS057278 5-methyl-1H-pyrazole-3-carboxylic acid, DAAO Inhibitor III A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910 nM against human DAO; [D-ser] = 10 mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50 mM) exposure (ED50 ≤3.95 µM), while exhibiting little affinity toward NMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80 mg/kg or 56X 20 mg/kg/12 h b.i.d. oral dosages) in vivo. 产品信息 Form White solid Primary Target DAAO Primary Target IC50 910 nM Molar mass 126.11 Protect from Light 是的 Packaged under inert gas 是的 Reversible 是的 Purity ≥99% by HPLC Solubility DMSO Chemical formula C5H6N2O2 CAS number 402-61-9 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling