CRAC Channel Inhibitor III, Pyr6 N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490 nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol (Cat. No. 212385) stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46 µM; by Fura-2). A great complement to Pyr2 (Cat. No. 203890), Pyr3 (Cat. No. 648490), and Pyr10 (Cat. No. 648494) in Ca2+ signaling studies. 产品信息 Form Light beige solid Primary Target Orai3 Primary Target IC50 490 nM Molar mass 418.3 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥99% by HPLC Solubility DMSO 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling