Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex ubiquitin ligase activity both in cell-free assays (by 100% against self- and Top2α ubiquitination at 25 and 50 µM, respectively) and in HeLa cells (by 100% against Bmi1 ubiquitination at 50 µM). Shown to greatly potentiate Teniposide (VM26) cancer cytotoxicity (by 10-fold in A375 and A549 cultures at 5.5 and 33 µM, respectively) by preventing Top2α degradation following VM26 treatment (100% inhibition at 50 µM in HeLa cells). 产品信息 Form Yellow powder Primary Target BMI1/RING1A Molar mass 235.2 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Reversible Q Purity ≥99% by HPLC Solubility DMSO CAS number 31083-55-3 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling