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Cadein1
1-Pentadecyl-6,7-dimethoxy-2-(2,6-difluorobenzyl)-3,4-dihydroisoquinolium chloride, Cancer-selective death inducer 1
A cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system, including HCT116-Ch3/E6, HeLa, HT29, and SW620 (viability <19 %; 4-6 µM Cadein1 for 24 h), while exhibiting much reduced potency in MMR-/p53+ (RKO and HCT116), MMR-/p53- (DLD-1 and HCT116-E6), and MMR+/p53+ (HCT116-Ch3 and HEK293) cancer cultures (viability = 40 to 92%; 4 µM Cadein1 for 24 h).
产品信息
Form Yellow powder
Molar mass 655.7
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C33H48F2INO2
商店和运输信息
Storage -20°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |