Akt Activator II, SC79 Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate A cell-permeable and blood-brain barrier permeant HA14-1 (Cat. No. 371971) analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO model (40 mg/kg, i.p.) in vivo. 产品信息 Form Off-white solid Primary Target Pleckstrin homology (PH) domain of Akt Molar mass 364.8 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Reversible Q Purity ≥98% by HPLC (sum of two isomers) Solubility DMSO CAS number 305834-79-1 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling