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InSolution™ Akt Inhibitor X
4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 10-(4′-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl
A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound (Cat. No. 124020) is also available.
产品信息
Form Liquid
Formulation A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H2O.
Primary Target Akt
Molar mass 381.4
Protect from Light 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥97% by HPLC
Chemical formula C20H25ClN2O • HCl
CAS number 925681-41-0
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |