Adenosine A3 Receptor Antagonist, MRS 1523

Adenosine A3 Receptor Antagonist, MRS 1523
3-propyl-6-ethyl-5[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate, MRS 1523, MRS-1523
A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9 nM for human A3R, and 113 nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6 µM and 2.05 µM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA (Cat. No. 119139) on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA (Cat. No. 119140)-induced bronchoconstriction in an allergic murine model.
产品信息
Form  Clear, colorelss oil
Primary Target  A3 Receptor
Primary Target Ki  18.9 nM
Molar mass  399.55
Protect from Light  是的
Packaged under inert gas  是的
Reversible  是的
Purity  ≥95% by HPLC
Solubility  DMSO
CAS number  212329-37-8
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling