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Adenosine A2B Receptor Antagonist I, MRS 1754
8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS-1754, MRS1754
A p-cyanoanilide xanthine derivative that acts as a highly selective, high affinity antagonist of adenosine A2B receptor (A2BR; Ki = 1.97 nM for human A2BR). Does not significantly affect other adenosine receptors (Ki = 403 nM, 503 nM, and 570 nM for human A1R, A2AR, and A3R, respectively). Exhibits some antagonist action on rat A1R (Ki = 16.8 nM). Shown to abolish the cardioprotective effects of NECA (Cat. No. 119140).
产品信息
Form White solid
Primary Target Adenosine A2B Receptor
Primary Target Ki 1.97 nM
Molar mass 486.5
Protect from Light 是的
Packaged under inert gas 是的
Reversible 是的
Purity ≥99% by HPLC
Solubility DMSO
CAS number 264622-58-4
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |