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Adenosine A1 Receptor Antagonist I, DPCPX
8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948
A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
产品信息
Form White solid
Primary Target A1
Primary Target Ki 3.9 nM
Molar mass 304.4
Protect from Light 是的
Packaged under inert gas 是的
Reversible 是的
Purity ≥99% by HPLC
Solubility DMSO
CAS number 102146-07-6
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |