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Anti-RAB8A
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-RAB8A Antibody
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Specificity:
This antibody recognizes the C-terminus of RAB8A.
Molecular Weight:
~24 kDa observed. Uncharacterized bands may be observed at ~110 kDa and ~38 kDa.
Epitope:
C-terminus
Immunogen:
KLH-conjugated linear peptide corresponding to the C-terminus of human RAB8A.
Background Information:
Ras-related protein Rab-8A (RAB8A) is one of two Rab8 isoforms, which belong to the superfamily of GTPases. They cycle between an active GTP-bound state, formed from interaction with guanine nucleotide exchange factors (GEFs) such as Rabin8 and GRAB; and an inactive GDP-bound state via interaction with GTPase activating proteins (GAPs) such as TBC1D1. Rab8A activates various effector molecules, which are coupled to intracellular signaling networks that mediate membrane and vesicular trafficking, and actin remodeling. Rab8A is found in the golgi network, perinuclear region, plasma membrane, lamellipodia, and cilia, among other regions.
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human. Predicted to react with Mouse and Bovine based on 100% sequence homology.
Application Notes:
Western Blot Analysis: A representative lot from an independent laboratory detected RAB8A in human cerebellum and brain.
Control:
Serum starved HeLa cell lysate
Quality Assurance:
Evaluated by Western Blot in serum starved HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected RAB8A in serum starved HeLa cell lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P61006
Entrez Gene Number:
NP_005361
Gene Symbol:
RAB8A
MEL
RAB8
Alternate Names:
Ras-related protein Rab-8A
Oncogene c-mel
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Product Name:
Anti-RAB8A
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit
Applications:
This Anti-RAB8A Antibody is validated for use in Western Blotting for the detection of RAB8A. |