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Anti-GCC185
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Species Reactivity Key Applications Host Format Antibody Type
H, M ICC, IHC Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-GCC185 Antibody
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Molecular Weight:
195 kDa calculated
Immunogen:
KLH-conjugated linear peptide corresponding to human GCC185.
Background Information:
GCC185 (GRIP and coiled-coil domain-containing protein 2), also known as GCC2, is a peripheral membrane protein that belongs to the Golgi-localized Golgin family of proteins. It is localized to the trans-Golgi network and regulates vesicular transport between the endosomes and the Golgi. GCC185 is needed for anchoring noncentrosomal microtubules from the Golgi and for receipt of transport vesicles inbound from late endosomes. GCC185 binds Rab6. The mutation of residues that are needed for Rab binding removes Golgi localization. GCC185 is needed for maintenance of the Golgi structure.
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Species Reactivity:
Human
Mouse
Species Reactivity Note:
Demonstrated to react with Human and Mouse.
Application Notes:
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected GCC185 in A431 and HeLa cells.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GCC185 in human breast cancer and human pancreas tissue.
Control:
NIH/3T3 cells
Quality Assurance:
Evaluated by Immunocytochemistry in NIH/3T3 cells.
Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected GCC185 in NIH/3T3 cells.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q8IWJ2
Entrez Gene Number:
NP_852118
Gene Symbol:
GCC2
KIAA0336
RANBP2L4
Alternate Names:
GRIP and coiled-coil domain-containing protein 2
185 kDa Golgi coiled-coil protein
GCC185
CLL-associated antigen KW-11
CTCL tumor antigen se1-1
Ran-binding protein 2-like 4
RanBP2L4
Renal carcinoma antigen NY-REN-53
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunocytochemistry
Immunohistochemistry
Product Name:
Anti-GCC185
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit
Applications:
Anti-GCC185 Antibody detects level of GCC185 & has been published & validated for use in 0. |