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SP600125
MAP Kinase Inhibitor - Autophagy Inhibitor - JNK inhibitor
SP600125 is a potent, cell-permeable, selective and reversible inhibitor of c-Jun N-terminal kinase (JNK) [1].
It inhibits in a dose-dependent manner the phosphorylation of JNK. JNK is a member of the mitogen-activated protein kinase (MAPK) family and plays an essential role in TLR mediated inflammatory responses [2, 3].
Inhibition of JNK activity by SP600125 is usually associated with downregulation of Beclin-1 and reduced autophagy.
Working concentration: 10-50 µM
CAS number: 129-56-6
Synonym: SAPK inhibitor II
Molecular weight: 220.2
Solubility: 100 mM in DMSO and 10 mM in ethanol
Purity: >99% (HPLC) |