LPS-SM Ultrapure

LPS-SM
Ultrapure LPS from Salmonella minnesota R595
Lipopolysaccharide (LPS) is the principal component of Gram negative bacteria that activates the innate immune system. LPS is recognized by Toll-like receptor 4 (TLR4) which interacts with three different extracellular proteins: LPS binding protein (LBP), CD14 and, myeloid differentiation protein 2 (MD-2), leading to the activation of NF-κB and the production of proinflammatory cytokines.
However, most LPS preparations on the market are contaminated by other bacterial components, such as lipoproteins, thus activating TLR2 signaling as well as TLR4 signaling. Ultra-pure LPS-SM was extracted by successive enzymatic hydrolysis steps and purified by the phenol-TEA-DOC extraction protocol.  Ultrapure LPS-SM only activates the TLR4 pathway.
Species : Salmonella enterica serovar minnesota mutant R595
Specificity: TLR4 agonist
Working concentration: 10 ng- 10 μg/ml
Endotoxin level: 1  x 105 EU/mg
Solubility: 5 mg/ml in water