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Polymyxin B
LPS-induced TLR4 activation inhibitor
Polymyxin B (PMB) is a cyclic cationic polypeptide antibiotic produced by the soil bacterium Paenibacillus polymixa. PMB blocks the biological effects of Gram negative lipopolysaccharide (LPS) through binding to lipid A, the toxic component of LPS, which is negatively charged [1,2]. The neutralizing effect of PMB on LPS is dose-related and specific for LPS [3]. PMB is widely used to eliminate the effects of endotoxin contamination, both in vitro and in vivo.
Working concentration: 10- 100 μg/ml
Endotoxin level: <0.125 EU/mg
Solubility: Water (50 mg/ml)
CAS number: 1405-20-5
Molecular weight: 1301.56 |