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PMA
NF-κB Activator
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA) is a specific activator of Protein Kinase C (PKC) and hence of NF-κB. PMA is the most commonly used phorbol ester. It is active at nanomolar concentrations. PMA causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter.
Working concentration: 100 ng - 1 µg/ml
CAS number: 16561-29-8
Formula: C36H56O8
Molecular weight: 616.8
Solubility: DMSO (5 mg/ml) |