HKSP Heat Killed Streptococcus pneumoniae Streptococcus pneumoniae, a Gram positive bacterium, is the principal etiologic agent of bacterial meningitis in adults. Heat-killed Streptococcus pneumoniae (HKSP) induce activation of NF-κB in a TLR2- and CD14-dependent manner [1]. TLR2 has been shown to play an important role in the protein- and polysaccharide-specific type 1 IgG isotype response following immunization with HKSP [2]. Specificity: TLR2 agonist Working concentration: 107-109 cells/ml Solubility: Insoluble (resuspended HKSP results in a cloudy suspension)