Hemozoin NLRP3 Inflammasome Inducer Hemozoin is a dark-brown heme crystal produced by the intraerythrocytic parasite Plasmodium, the causative agent of malaria. Hemozoin is taken up by macrophages initiating signals that lead to the production of IL-1β. Hemozoin-induced IL-1β production is dependent on the activation of the NLRP3 inflammasome [1,2]. Synthetic hemozoin has been shown to possess adjuvant properties that differ depending on the method of synthesis [3]. InvivoGen provides a chemically synthesized hemozoin using an acidic method. Working concentration: 50 - 400 µg/ml Solubility: Insoluble. Rehydration of hemozoin with water or saline results in a dark brown suspension.