HKPG Heat Killed P. gingivalis KPG is a freeze-dried heat-killed preparation of the periodontopathic bacteria Porphyromonas gingivalis. In chinese hamster ovary (CHO) cells cotransfected with CD14 and TLR2, exposure to HKPG induces the activation of NF-κB dose dependently indicating that TLR2 plays an important role in the recognition of these bacteria. Expression of TLR4 failed to enhance the response to HKPG suggesting that either the whole bacterial components of P. gingivalis are not recognized by TLR4 or some components of these bacteria inhibit TLR4-mediated activation [1]. Specificity: TLR2 agonist Working concentration: 106-108 cells/ml Solubility: Insoluble (resuspended HKPG results in a cloudy suspension)