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HKLP
Heat Killed Legionella pneumophila
Legionella pneumophila, a Gram negative bacterium, is the causative agent of legionnaires’ disease which is characterized by severe pneumonia. Although TLR4 is involved in host defense against gram negative bacteria infection, it is not activated or is activated only to a limited extent by L.pneumophila [1]. L. pneumophila requires TLR2 rather than TLR4 to induce the production of cytokines [2]. Stimulation with heat-killed L. pneumophila (HKLP) induces the activation of NF-κB in TLR2-expressing HEK293 cells but not in TLR4-expressing HEK293 cells.
Specificity: TLR2 agonist
Working concentration: 107-108 cells/ml
Solubility: Insoluble (resuspended HKLP results in a cloudy suspension) |