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Anti-ASIP, clone EP310Y, Rabbit Monoclonal
Species Reactivity Key Applications Host Format Antibody Type
H WB, FC Rabbit Diluted Culture Supernatant Monoclonal Antibody
Description:
Anti-ASIP Antibody, clone EP310Y, rabbit monoclonal
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Specificity:
This antibody recognizes ASIP near the C-terminus and is predicted to detect isoforms 2-7 based on sequence analysis.
Molecular Weight:
~150 kDa observed
Epitope:
C-terminus
Immunogen:
Synthetic peptide corresponding to human ASIP near the C-terminus.
Clone:
EP310Y
Isotype:
IgG
Background Information:
The agouti signaling protein (ASIP) is an adaptor protein involved in asymmetrical cell division and cell polarization processes. ASIP seems to play a central role in the formation of epithelial tight junctions. ASIP may affect the quality of hair pigmentation, and act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone (2-3). ASIP may also play a role in neuroendocrine aspects of melanocortin action, and have a functional role in regulating lipid metabolism in adipocytes (4-5).
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with human.
Application Notes:
Flow Cytometry Analysis: 1:20 dilution from a representative lot was used in FC.
Control:
LNCap, HeLa, A431, and MCF-7 cell lysates
Quality Assurance:
Evaluated by Western Blot in LNCap, HeLa, A431, and MCF-7 cell lysates.
Western Blot Analysis: 1:500 dilution of this antibody detected ASIP in LNCap, HeLa, A431, and MCF-7 cell lysates.
Purification Method:
Unpurified
Presentation:
Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Conditions:
Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot intomicrocentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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UniProt Number:
Q8TEW0
Entrez Gene Number:
Q8TEW0
Gene Symbol:
PAR3
ASIP
Bazooka
Baz
PARD3A
PAR3-alpha
PARD-3
SE2-5T2
PAR3alpha
OTTHUMP00000019427
SE2-5L16
FLJ21015
SE2-5LT1
OTTHUMP00000019434
PAR-3
PAR3A
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Alternate Names:
par-3 partitioning defective 3 homolog (C. elegans)
Atypical PKC isotype-specific-interacting protein
CTCL tumor antigen se2-5
par-3 (partitioning defective 3, C.elegans) homolog
atypical PKC isotype-specific interacting protein
partitioning defective 3 homolog2
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Flow Cytometry
UniProt Summary:
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central ro |