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Anti-Potassium Channel Kv1.2, clone K14/16
Species Reactivity Key Applications Host Format Antibody Type
R IHC, WB, IF Mouse Purified Monoclonal Antibody
Description:
Anti-Potassium Channel Kv1.2 Antibody, clone K14/16
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Molecular Weight:
~ 65 kDa observed
Immunogen:
Recombinant protein corresponding to rat Kv1.2.
Clone:
K14/16
Isotype:
IgG2bκ
Background Information:
Potassium channel Kv1.2 is one of many different types of potassium channels in the cell. The Kv family of potassium channels seem to have a conserved homotetramer formation consisting of four voltage sensors and one pore domain. Kv1.2 cooperates with cortactin (an actin cytoskeleton-binding protein) and together they may have a part in the regulation of the ionic current.
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Species Reactivity:
Rat
Species Reactivity Note:
Demonstrated to react with rat.
Application Notes:
Immunofluorescence Analysis: a previous lot of this antibody was used by an independent laboratory in IF. (Yang, J.W., et al. (2007). PNAS. 104(50):20055–20060.)
Control:
Rat brain membrane tissue lysate
Quality Assurance:
Evaluated by Western Blot in rat brain membrane tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Kv1.2 on 10 µg of rat brain membrane tissue lysate.
Purification Method:
Protein G
Presentation:
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P63142
Entrez Gene Number:
NP_037102
Gene Symbol:
KCNA2
HBK5
RBK2
HK4
MK2
KV1.2
NGK1
HUKIV
Kv1.2
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Alternate Names:
potassium voltage-gated channel, shaker-related subfamily, member 2
potassium voltage-gated channel subfamily A member 2
Voltage-gated potassium channel subunit Kv1.2
Voltage-gated potassium channel HBK5
potassium channel
Voltage-gated K(+) channel HuKIV
voltage-gated potassium channel protein Kv1.2
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry
Western Blotting
Immunofluorescence
Entrez Gene Summary:
Delayed-rectifier K+ channel expressed in heart and brain [RGD].
UniProt Summary:
FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
SUBUNIT STRUCTURE: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DOMAIN: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltag |