Anti-Neuroligin-3, clone N110/29

Anti-Neuroligin-3, clone N110/29
Species Reactivity Key Applications Host Format Antibody Type
R  IHC, WB Mouse Purified Monoclonal Antibody
Description:
Anti-Neuroligin-3 Antibody, clone N110/29
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Specificity:
This antibody recognizes Neuroligin-3 at the cytoplasmic domain.
Molecular Weight:
~ 90 kDa observed
Epitope:
Cytoplasmic domain
Immunogen:
Recombinant protein corresponding to rat Neuroligin-3 at the cytoplasmic domain.
Clone:
N110/29
Isotype:
IgG1κ
Background Information:
Neuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses.
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Species Reactivity:
Rat
Species Reactivity Note:
Demonstrated to react with rat.
Application Notes:
Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Neuroligin-3 in rat brain (putamen area) and rat cerebellum tissue.
Control:
Rat brain membrane tissue lysate
Quality Assurance:
Evaluated by Western Blot in rat brain membrane tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Neuroligin-3 on 10 µg of rat brain membrane tissue lysate.
Purification Method:
Protein G
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q62889
Entrez Gene Number:
NP_599163
Gene Symbol:
NLGN3
HNL3
NL3
AUTSX1
ASPGX1
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Alternate Names:
Gliotactin homolog
Neuroligin-3
neuroligin 3
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry
Western Blotting
Entrez Gene Summary:
Neuronal cell surface protein that binds neurexins [RGD].
UniProt Summary:
FUNCTION: Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
SUBUNIT STRUCTURE: Interacts with neurexin 1-beta isoform 3/Beta 4B5A and isoform 4/Beta 4B5B. Interacts with neurexin 2-beta isoform 3/Beta 4B5A, isoform 4/Beta 4B5B, isoform 7/Beta 4B5A6 and isoform 8/Beta 4B5B6. Interacts with corresponding neurexin 3-beta isoforms. Probably interacts through its C-terminus with DLG4/PSD-95 third PDZ domain (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICTY: Expressed in brain