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Anti-alpha B-crystallin, clone CPTC-CRYAB-1
Species Reactivity Key Applications Host Format Antibody Type
H WB Mouse Purified Monoclonal Antibody
Description:
Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1
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Molecular Weight:
~20 kDa observed
Immunogen:
Full length recombinant protein corresponding to human alpha B-crystallin.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Clone:
CPTC-CRYAB-1
Isotype:
IgG2aκ
Background Information:
Alpha B-crystallin is a heat shock chaperone protein, up-regulated by stress. It has been shown to be expressed in the vertebrate eye lens and also found in cardiac and skeletal muscles, the kidney and the brain. Alpha B-crystallin is also found to be a component of Rosenthal fibers and a consistent tissue marker of epileptic foci.
Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with human.
Control:
Human heart tissue lysate
Quality Assurance:
Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected alpha B-crystallin on 10 µg of human heart tissue lysate.
Purification Method:
Protein G
Presentation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P02511
Entrez Gene Number:
NP_001876
Gene Symbol:
CRYAB
CTPP2
HspB5
Bcrystallin
CRYA2
HSPB5
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Alternate Names:
crystallin, alpha B
alpha(B)-crystallin
heat-shock 20 kD like-protein
alpha-crystallin B chain
Rosenthal fiber component
alpha crystallin B chain
Renal carcinoma antigen NY-REN-27
alpha B crystallin
Heat shock protein beta-5
Alpha(B)-crystallin
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational |