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AG 1296
6,7-Dimethoxy-3-phenylquinoxaline
Similar to but more potent than AG 1295 (Cat. No. 658550). A cell-permeable, reversible, and ATP-competitive, inhibitor of PDGF receptor kinase and blocks signaling of human PDGF α-receptors (IC50 = 1.0 µM) and β-receptors (IC50 = 800 nM) as well as of the related stem cell factor receptor c-kit (80% inhibition at 5 µM). Affects neither the binding of PDGF-BB to the PDGF-β receptor nor the receptor dimerization. Has no effect on autophosphorylation of the vascular endothelial growth factor receptor KDR or on DNA synthesis induced by vascular endothelial growth factor in porcine aortic endothelial cells. Also reverses the transformed phenotype of sis-transfected NIH/3T3 cells but has no effect on src-transformed NIH 3T3 cells or on the activity of the kinase p60c-src (F257) immunoprecipitated from these cells. Potently inhibits autophosphorylation in Flt3/Tel-BaF3 and Flt3/Itd-BaF3 cells with an IC50 of 300 nM and ~1 µM, respectively.
产品信息
Form White solid
Primary Target PDGFR kinase
Primary Target IC50 1 µM
Secondary target β-receptors (IC50 = 800 nM)
Molar mass 266.3
Protect from Light 是的
Purity ≥98% by HPLC
Solubility DMSO or ACN
Chemical formula C16H14N2O2
CAS number 146535-11-7
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |