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AG 1478
4-(3-Chloroanilino)-6,7-dimethoxyquinazoline
A cell-permeable, reversible, ATP-competitive, highly potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 = 3 nM) versus HER2-neu (IC50 >100 µM) and platelet-derived growth factor receptor kinase (IC50 >100 µM). Abolishes MAP kinase (ERK) activation induced by Angiotensin II (Cat. No. 05-23-0101). Also inhibits the activation of EGFR kinase and MAP kinase by 4-hydroxynonenal. Downregulates ARF1 activity and disperses Golgi structure. A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658548) in DMSO is also available.
产品信息
Form Pale yellow solid
Primary Target epidermal growth factor receptor kinase
Primary Target IC50 3 nM
Secondary target activation of EGFR kinase and MAP kinase by 4-hydroxynonenal
Molar mass 315.8
Protect from Light 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C16H14ClN3O2
CAS number 175178-82-2
Declaration Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |