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AG 1295
6,7-Dimethyl-2-phenylquinoxaline
A cell-permeable, reversible, ATP-competitive, and selective inhibitor of platelet-derived growth factor (PDGF) receptor kinase (IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 µM) in Swiss/3T3 cells. Has no effect on EGF receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis. A potent blocker of smooth muscle cell proliferation.
产品信息
Form White solid
Primary Target PDGFR kinase
Primary Target IC50 500 nM
Secondary target PDGF-dependent DNA synthesis (IC50 = 2.5 µM) in Swiss/3T3 cells
Molar mass 234.3
Protect from Light 是的
Purity ≥95% by HPLC
Solubility DMSO or CH2Cl2
Chemical formula C16H14N2
CAS number 71897-07-9
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |