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GGTI-298
N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA
A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC50 = 3 µM) but has no effect on the processing of H-Ras even at concentrations of 15 µM. Inhibits PDGF-receptor tyrosine phosphorylation. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis, and enhances iNOS induction by IL-1β.
产品信息
Form White solid
Formulation Supplied as a trifluoroacetate salt.
Primary Target Rap1a
Primary Target IC50 3 µM
Molar mass 479.6
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥90% by HPLC
Solubility DMSO
Chemical formula C27H33N3O3S
CAS number 180977-44-0
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |