GGTI-286 N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC50 = 2 µM vs. 50 µM) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50 = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells. 产品信息 Form Glassy solid Formulation Supplied as a trifluoroacetate salt. Primary Target GGTase Primary Target IC50 2 µM Secondary target K-Ras4B (IC50 = 2 µM) Molar mass 429.6 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥90% by HPLC Solubility DMSO Chemical formula C23H31N3O3S CAS number 171744-11-9 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling