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DNA-PK Inhibitor III|正品原装
产品信息：
Form Off-white solid
Primary Target DNA-PK
Primary Target IC50 120 nM
Secondary target PI 3-Kinase catalytic subunit p110b (IC50 = 135 nM), DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC50 = 68 µM)
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥95% by HPLC
Chemical formula C12H15NO3
CAS number 404009-40-1
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic
产品说明：
A cell-permeable aryl-morpholino compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 120 nM) and PI 3-Kinase catalytic subunit p110β (IC50 = 135 nM). It inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC50 = 68 µM) and enhances DSB-induced antitumor activity both in vitro and in vivo, while exhibiting no cytotoxic effects (up to 50 µM) in the absence of DSBs. It inhibits PI 3-K p110α, p110γ, and p110δ only at much higher concentrations (IC50 = 1.4, 0.88, and 1.0 µM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 µM. |