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产品信息：
Form Crystalline solid
Primary Target DNA-PK
Primary Target IC50 0.23 µM
Secondary target IC50 = 13 µM for PI3K and >100 µM for ATM and ATR
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Chemical formula C17H15NO3
CAS number 154447-35-5
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic
产品说明：
A cell-permeable benzochromenone compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK with an IC50 of 0.23 µM. It is highly selective towards DNA-PK over PI3K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR) and has no effect on PARP-1. Inhibits DNA-PK-mediated, but not PARP-1-mediated, cellular DNA DSB (double strand break) repair and PLDR (potentially lethal damage recovery) following IR (ionizing radiation). Shown to sensitize both proliferating and quiescent cells to IR. |