Cyclopamine, V. californicum A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10 mM solution in Ethanol (Cat. No. 239806). 产品信息 Form Off-white solid Primary Target Hh signaling in Shh-light2 assay Primary Target IC50 20 nM Secondary target in P2Ptch-/-cells (IC50 = 50 nM) Molar mass 411.6 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥97% by HPLC Solubility DMSO, EtOH, or DMF Chemical formula C27H41NO2 RTECS GY0750000 CAS number 4449-51-8 商店和运输信息 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Carcinogenic / Teratogenic