Cyclopamine-KAAD 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Also available as a 1 mM solution in DMSO (Cat. No. 239807). 产品信息 Form Pale yellow solid Primary Target Hh signaling in Shh-light2 assay Primary Target IC50 20 nM Secondary target in P2Ptch-/-cells (IC50 = 50 nM) Molar mass 698.0 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥70% by HPLC (sum of two isomers) Solubility DMSO, EtOH, or MeOH Chemical formula C44H63N3O4 商店和运输信息 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Harmful 安全标示 S Phrase S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves. R Phrase R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.