CURCUMIN, CURCUMA LONGA L. 产品信息 Form Orange-yellow solid Primary Target 5-lipoxygenase Primary Target IC50 8 µM Secondary target cyclooxygenase (IC50 = 52 µM), induction of nitric oxide synthase in activated macrophages (IC50 = 6 µM) Protect from Light 是的 Cell permeable 是的 Purity ≥80% by HPLC Chemical formula C21H20O6 RTECS MI5230000 CAS number 458-37-7 Merck USA index 14, 2673 Storage +15°C to +30°C Ship Ambient Temperature Only Standard Handling 产品说明 A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC50 = 8 µM) and cyclooxygenase (IC50 = 52 µM). Confers significant protection against neurotoxic and genotoxic agents. Also inhibits the induction of nitric oxide synthase in activated macrophages (IC50 = 6 µM). Recently shown to inhibit the EGF receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells in a dose- and time-dependent manner. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC50 of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).