COMPLEMENT C4, HUMAN

Complement C4, Human
Native, human C4 complement component. Glycoprotein composed of three non-identical subunits of M.W. of 93 kDa (α), 75 kDa (β), and 32 kDa (γ) linked by disulfide bonds. Present in normal human serum at 400 µg/ml. On activation of complement via the classical pathway, the C1s subcomponent of the C1 complex is converted to an active serine protease that cleaves the C4 α-chain at peptide bond 77, resulting in production of C4a (M.W. 8740) and C4b fragments (M.W. 193 kDa). The released C4a peptide is one of the three complement-derived anaphylatoxins. The nascent C4b fragment can form a covalent ester bond with target surfaces. This covalent attachment of C4b to target acceptors is required for continuation of activation via classical pathway.
产品信息
Form  Liquid
Formulation  In PBS, pH 7.2.
Molar mass  200000
Avoid freeze/thaw  是的
Specific activity  >3X105 C4H50 units/mg
Biological activity  ≥60% of the C4 activity present in freshly drawn normal human serum on a mg to mg basis
Purity  ≥90% by SDS-PAGE
Source  Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number  80295-48-3
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Standard Handling