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Complement C5, Human
Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120 kDa (α) and 75 kDa (β) linked by disulfide bonds. Present in normal human serum at 70 µg/ml. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).
产品信息
Form Liquid
Formulation In PBS, pH 7.2.
Molar mass 195000
Avoid freeze/thaw 是的
Biological activity ≥100,000 C5H50 units/mg; ≥60% of the C5 activity in normal human serum on a mg/mg basis
Purity ≥95% by SDS-PAGE
Contaminants IgG, IgA, IgM, albumin, ceruloplasmin or functionally C3, C6, C7, C8, or C9: ≤trace amounts
Source Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number 80295-53-0
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |