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Complement C1q, Human
Native, human C1q complement component. Glycoprotein composed of 18 polypeptide chains consisting of three nonidentical subunits, A, B, and C, of M.W. 29 kDa, 26 kDa, and 19 kDa, respectively. Present in normal human serum at 70 µg/ml. Found in circulating blood plasma complexed with two C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of C1q to immune complexes containing IgG or IgM or to a variety of other activating substances, including C-reactive protein, retroviruses, and mitochondria. Subsequent to C1q binding, C1r and C1s are converted to proteolytic enzymes that are responsible for continuation of activation via the classical pathway.
产品信息
Form Liquid
Formulation In 300 mM NaCl, 10 mM HEPES, 40% glycerol, pH 7.2.
Molar mass 410000
Avoid freeze/thaw 是的
Biological activity ≥150,000 C1qH50 units/mg and ≥70% C1q activity in normal human serum on a mg/mg basis
Purity ≥90% by SDS-PAGE
Contaminants IgG, IgA, IgM, C3, C4, albumin, fibrinogen, α2-macroglobulin: ≤trace amounts
Source Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number 80295-33-6
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |