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Complement C1r, Human, Activated, Two-Chain Form
Native, human, activated, C1r complement component. Generally the non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35 kDa peptide contains C1r enzymatic active site. Activated C1r continues activation via classical pathway by cleaving, and thus activating C1s.
产品信息
Form Liquid
Formulation In 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.
Molar mass 95000
Avoid freeze/thaw 是的
Biological activity ≥90% of C1r will bind with excess C1-INH
Purity ≥90% by SDS-PAGE
Contaminants IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH: ≤trace amounts
Source Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number 80295-34-7
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |