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Bcl-2 Inhibitor II, YC137
2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester
A cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9.
产品信息
Form Red solid
Molar mass 511.6
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥90% by HPLC
Solubility DMSO or EtOH
Chemical formula C24H21N3O6S2
CAS number 810659-53-1
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |