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Bcl-2 Inhibitor III, EM20-25
5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
A cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.
产品信息
Form Pale yellow solid
Molar mass 376.7
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by elemental analysis
Solubility DMSO
Chemical formula C15H9ClN4O6
CAS number 141266-44-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful |