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Bcl-2 Inhibitor
2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5′-Dimethoxy-2,2′-dinitrosobenzyl (B)
Contains mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-xLin vitro (IC50 = 10 µM and 7 µM, respectively). Reduces cell viability and growth in the HL-60 cell line with high Bcl-2 expression (IC50 = 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.
产品信息
Form Green solid
Molar mass 300.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by TLC
Solubility DMSO
Chemical formula C16H16N2O4
CAS number 383860-03-5
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Standard Handling |