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Integrin β1β3 Investigator Kit
Description:
Integrin β1β3 Investigator Kit
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Trade Name:
Chemicon (Millipore)
Product Overview:
Millipore Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators involved with this rapidly expanding field of study. The beta1 / beta3 Integrin Investigator Kit is designed for research focused on the expression of integrin beta1 and beta3 subunits. The beta1 / beta3 Integrin Investigator Kit contains 100 μg each of Cy5-conjugated mouse anti-integrin beta3 and Fluorescein-conjugated mouse anti- integrin beta1 monoclonal antibodies.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator. The combination of Cy5 and Fluorescein labels permits simultaneous labeling of integrins beta3 and beta1 in flow cytometry or immunofluorescence.
This kit or reagents are not intended for use in a diagnostic or clinical setting.
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Species Reactivity:
Human
Presentation:
100 μg each of monoclonals to beta1 and beta3, labeled with FITC and CY5, respectively.
Storage Conditions:
Store antibodies at 2-8°C. Protect from light.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid entrapped in the container's cap during shipment.
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UniProt Number:
P05556
Entrez Gene Number:
NM_002211.2
NM_033666.1
NM_033667.1
NM_033668.1
NM_033669.1
NM_133376.1
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Gene Symbol:
ITGB1
GPIIA
VLAB
OTTHUMP00000063732
MDF2
FNRB
OTTHUMP00000063731
OTTHUMP00000046253
CD29
OTTHUMP00000063733
MSK12
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Components:
Integrin beta3 Cy5-conjugated Mouse Monoclonal Antibody (Part No. MAB1957S-100)- 1 tube, 100 μg.
Integrin beta1 Fluorescein-conjugated Mouse Monoclonal Antibody (Part No. MAB1951F-100)- 1 tube, 100 μg.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane re |