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αVβ3/PECAM Investigator Kit
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PRODUCT FAMILY INFORMATION
CD31 Antibodies
Millipore’s CD31 antibodies demonstrates specificity against platelet endothelial cell adhesion molecule 1 (PECAM1). See below for products for CD31, based on the expertise of Upstate & Chemicon.
Millipore’s CD31 antibody demonstrates specificity against CD31. See below for data and references for Millipore’s CD31 antibodies. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Description:
αVβ3/PECAM Investigator Kit
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Trade Name:
Chemicon (Millipore)
Product Overview:
Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators involved with this rapidly expanding field of study. The alphaVbeta3 / PECAM Integrin Investigator Kit is designed for research focused on the presence of the human alphaVbeta3 integrin subunit on PECAM-1 [CD31] expressing cells. The alphaVbeta3 / PECAM Integrin Investigator Kit contains 100 mg each of Cy5-conjugated mouse anti-integrin alphaVbeta3 and Fluorescein-conjugated mouse anti-PECAM-1 [CD31] monoclonal antibodies.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator. The combination of Cy5 and Fluorescein labels permits simultaneous labeling of Integrin alphaVbeta3 and PECAM in flow cytometry or immunofluorescence.
This kit and reagents is not intended for use in a diagnostic or clinical setting.
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Species Reactivity:
Human
Presentation:
100 μg each of monoclonals to alphaVbeta3 and PECAM, labeled with CY5 and FITC, respectively.
Storage Conditions:
Store antibodies at 2-8°C. Protect from light.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid entrapped in the container's cap during shipment.
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UniProt Number:
P06756
Entrez Gene Number:
NM_002210.2
Gene Symbol:
ITGAV
CD51
DKFZp686A08142
VNRA
MSK8
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Components:
Integrin alphaVbeta3 Cy5-conjugated Mouse Monoclonal Antibody (Part No. MAB1976S-100)- 1 tube, 100 μg.
PECAM [CD31] Fluorescein-conjugated Mouse Monoclonal Antibody (Part No. MAB2148F-100)- 1 tube, 100 μg.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in |