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Anti-NAG-1/PTGFβ Antibody
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REFERENCES
Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs.
Eva Lincová,Ales Hampl,Zuzana Pernicová,Andrea Starsíchová,Pavel Krcmár,Miroslav Machala,Alois Kozubík,Karel Soucek (2009) Biochemical pharmacology.78
Impact of constitutive IGF1/IGF2 stimulation on the transcriptional program of human breast cancer cells.
Margit Pacher, Michael J Seewald, Mario Mikula, Susanne Oehler, Maurice Mogg, Ursula Vinatzer, Andreas Eger, Norbert Schweifer, Roland Varecka, Wolfgang Sommergruber, Wolfgang Mikulits, Martin Schreiber (2007) Carcinogenesis.28:49-59
Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities.
Baek, S J, et al. (2001) Mol. Pharmacol., 59: 901-8 (2001)
Species Reactivity Key Applications Host Format Antibody Type
H IHC, WB Rabbit Purified Polyclonal Antibody
Description:
Anti-NAG-1/PTGFβ Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes pro- and secreted- forms of NAG-1/PTGF-beta.
Molecular Weight:
35 kDa (pro-form) and 10-15 kDa (secreted form)
Immunogen:
peptide corresponding to amino acids 287-302 (K-KTDTGVSLQTYDDLLA) of human NAG-1/PTGF-b/PLAB/PDF/ MIC-1/HP00269
Isotype:
IgG
Species Reactivity:
Human
Control:
HCT-116 cell lysate
Quality Assurance:
routinely evaluated by immunoblot on a HCT-116 cell lysate
Purification Method:
Protein A purfied
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
Q99988
Entrez Gene Number:
NM_004864
Gene Symbol:
GDF15
GDF-15
PDF
MIC1
MIC-1
NAG-1
NRG-1
PTGFB
PTGF-beta
PLAB
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry
Western Blotting
Entrez Gene Summary:
Bone morphogenetic proteins (e.g., BMP5; MIM 112265) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM]
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UniProt Summary:
SIZE: 308 amino acids; 34168 Da
SUBUNIT: Homodimer; disulfide-linked (By similarity).
SUBCELLULAR LOCATION: Secreted (Probable).
TISSUE SPECIFICITY: Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.
SIMILARITY: SwissProt: Q99988 ## Belongs to the TGF-beta family.
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