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Anti-Retinoid X Receptor α, clone 4E9
Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC Mouse Purified Monoclonal Antibody
Description:
Anti-RXR alpha Antibody, clone 4E9
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Specificity:
This antibody detects Retinoid X Receptor α.
Molecular Weight:
51 kDa
Immunogen:
GST-tagged recombinant protein corresponding to Retinoid X Receptor α.
Clone:
4E9
Isotype:
IgG2aκ
Background Information:
Retinoid X receptor α (RXRA or RXR alpha) is a nuclear receptor that mediates the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRs as a whole exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulate their transcription.
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Species Reactivity:
Human
Species Reactivity Note:
Human
Application Notes:
Immunocytochemistry: Representative lot data.
A 1:500 dilution of a previous lot detected Retinoid X Receptor α in A431 cells.
Control:
MCF-7 cell lysate
Quality Assurance:
Evaluated by western blot on MCF-7 cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Retinoid X Receptor α in MCF-7 cell lysate.
Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8ºC from date of receipt.
UniProt Number:
P19793
Entrez Gene Number:
NP_002948.1
Gene Symbol:
FLJ00280
FLJ00318
FLJ16020
FLJ16733
MGC102720
NR2B1
OTTHUMP00000022510
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Alternate Names:
Nuclear receptor subfamily 2 group B member 1
Retinoid X receptor alpha
retinoid X receptor, alpha
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunocytochemistry
Entrez Gene Summary:
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq].
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UniProt Summary:
FUNCTION: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer By similarity.
SUBUNIT STRUCTURE: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with FAM120B By similarity. Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6. In |