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Anti-Fibroblast Growth Factor Receptor 1, clone VBS1
Recommended Replacement for: MAB125
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Ch, B WB, IP, IH(P), ELISA Mouse Purified Monoclonal Antibody
Description:
Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1
Replaces:
MAB125
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Specificity:
This antibody recognizes the extracellular ligand-binding domain of Fibroblast Growth Factor Receptor 1.
Molecular Weight:
~92 kDa
Epitope:
Extracellular
Immunogen:
FGF Receptor purified from bovine coronary venular endothelial cells.
Clone:
VBS1
Isotype:
IgM
Background Information:
The fibroblast growth factor receptors are members of the tyrosine kinase superfamily and consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. (Ornitz, DM. and Itoh, N) Monoclonal antibodies against the high affinity tyrosine kinase Fibroblast Growth Factor (FGF) receptor may help define receptor epitopes involved in FGF binding and signal transduction which mediate coronary and tumor angiogenesis. (Venkateswaran, S., et al).
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Species Reactivity:
Human
Mouse
Rat
Chicken
Bovine
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Species Reactivity Note:
Demonstrated to react with human, mouse, rat, cow and chicken.
Application Notes:
Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH(P) (Venkateswaran, S., et al)
Control:
NIH/3T3 cell lysate
Quality Assurance:
Evaluated by Western Blotting in NIH/3T3 cell lysate.
Western Blotting Analysis: 0.78 µg/mL of this antibody detected Fibroblast Growth Factor Receptor 1 in 10 µg of NIH/3T3 cell lysate.
Purification Method:
Protein A purfied
Presentation:
Purified mouse monoclonal IgM in 0.015 M potassium phosphate buffer containing 0.15 M NaCl, 0.1% sodium azide, pH 7.20.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P11362
Entrez Gene Number:
NP_001103677.1
Gene Symbol:
CD331
CEK
EC 2.7.10.1
FGFBR
FGFR-1
FLG
FLJ99988
FLT2
H2
H3
H4
H5
HBGFR
KAL2
N-SAM
OGD
OTTHUMP00000190874
OTTHUMP00000190878
OTTHUMP00000190879
OTTHUMP00000190881
bFGF-R
c-fgr
BFGFR
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Alternate Names:
CD331 antigen
Fms-like tyrosine kinase 2
basic fibroblast growth factor receptor 1
fibroblast growth factor receptor 1
fms-related tyrosine kinase 2
heparin-binding growth factor receptor
hydroxyaryl-protein kinase
soluble FGFR1 variant 1
soluble FGFR1 variant 2
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunoprecipitation
Immunohistochemistry (Paraffin)
ELISA
UniProt Summary:
FUNCTION: Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL By similarity. A shorte |