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Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal
Species Reactivity Key Applications Host Format Antibody Type
H, M, Vrt WB, IF Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal
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Specificity:
This antibody detects p38α when phosphorylated on Thr180/Tyr182.
Molecular Weight:
38 kDa
Epitope:
Phosphorylated Thr180/Tyr182
Immunogen:
Synthetic peptide corresponding to amino acids surrounding and including phosphorylated Thr180/Tyr182 of human p38α.
Modifications:
Phosphorylation
Clone:
8.78.8
Isotype:
IgG
Background Information:
The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation.
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Species Reactivity:
Human
Mouse
Vertebrates
Species Reactivity Note:
Human and Mouse tested. Predicted to cross-react with many other species based on 100% sequence homology with immunogen.
Quality Assurance:
Evaluated by western blot on anisomycin-treated HeLa cell lysate.
Western Blot Analysis: 1:5,000-1:10,000 dilution of this antibody was used to detect p38 phosphorylated on Thr180/Tyr182 in anisomycin-treated HeLa and NIH/3T3 cell lysate.
Presentation:
Rabbit monoclonal antibody in culture supernatant containing 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at -20ºC from date of receipt.
UniProt Number:
Q15759
Entrez Gene Number:
NP_001306
Gene Symbol:
P38B
P38BETA2
PRKM11
SAPK2
SAPK2B
p38-2
p38Beta
p38b
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Alternate Names:
CSAID-binding protein
Csaids binding protein
Cytokine suppressive anti-inflammatory drug-binding protein
MAP kinase MXI2
MAP kinase p38 alpha
MAX-interacting protein 2
Mitogen-activated protein kinase p38 alpha
cytokine suppressive anti-inflammatory drug binding protein
mitogen-activated protein kinase 14
p38 MAP kinase
p38 mitogen activated protein kinase
p38alpha Exip
stress-activated protein kinase 2A
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of c |