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Anti-phospho-CRKL (Tyr207), clone 7.124.12
Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-phospho-CRKL (Tyr207) Antibody, clone 7.124.12, rabbit monoclonal
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Specificity:
Reacts with phosphorylated human CRKL .
Molecular Weight:
~39 kDa
Epitope:
Phosphorylated Tyr207
Immunogen:
KLH-conjugated synthetic peptide surrounding phosporykated tyrosine amino acid 207 of human CRKL.
Modifications:
Phosphorylation
Clone:
clone 7.124.12
Isotype:
IgG
Background Information:
CRKL is a 39 kDa adaptor protein with one SH2 and two SH3 binding domains. CRKL is the major protein which is tyrosine phosphorylated in response to BCR/ABL (chronic myelogenous leukemia) and growth factor activation. In myeloid cells, it binds to proteins such as paxillin, p130cas and p120 cbl. CRKL aslo appears to bind ABL and SOS.
Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Reacts with human. Predicted to cross react with mouse and rat, based on 100% sequence homology. Reactivity with other species has not been tested.
Control:
K562 cell lysate
Quality Assurance:
Evaluated on a representative lot by Western blot in K562 cell lysates.
Presentation:
Supernatant containing 0.05% NaN3.
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
P46109
Entrez Gene Number:
P46109
Alternate Names:
v-crk avian sarcoma virus CT10 oncogene homolog-like
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: May mediate the transduction of intracellular signals.
SUBUNIT STRUCTURE: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.
SEQUENCE SIMILARITIES: Contains 1 SH2 domain.
Contains 2 SH3 domains.
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Product Name:
Anti-phospho-CRKL (Tyr207), clone 7.124.12
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 μL
Format:
Culture Supernatant
Host:
Rabbit
Applications:
Anti-phospho-CRKL (Tyr207) Antibody, clone 7.124.12 detects level of phospho-CRKL (Tyr207) & has been published & validated for use in WB. |